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Taking reasonable amounts of milk thistle supplements is safe. However, how much does it take to reach the optimum effect of protecting and improving your liver function and health? When searching for the best milk thistle supplement, find one that binds silymarin to phosphatidylcholine, a member of the Lecithin group. This substance is proven to enhance milk thistle benefits up to ten times. This new form can also be easily absorbed by the body, providing more health benefits.